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Detection of breastmilk antibodies targeting SARS-CoV-2 nucleocapsid, spike and receptor-binding-domain antigens.

Published version
Peer-reviewed

Repository DOI


Type

Article

Change log

Authors

Ceron-Gutierrez, ML 
Carnell, GW 
Heeney, JL 
Corrie, P 

Abstract

A 40-year-old female was found to have strongly neutralizing SARS-CoV-2 breastmilk IgA and IgG antibodies reactive against multiple SARS-CoV-2 antigens at 2.5 months after documented infection with SARS-CoV-2. At 6.5 months following the infection, she remained positive for breastmilk and serum SARS-CoV-2 neutralizing antibodies. Holder breast milk pasteurization did not diminish SARS-CoV-2 antibody titres but it reduced its neutralizing capacity, while serum heat inactivation had no negative effect on SARS-CoV-2 serum antibody levels and neutralizing capacity. Current data on SARS-CoV-2 and breastmilk are reviewed.

Description

Keywords

COVID-19, IgA, IgG, SARS-CoV-2, antibody, breastmilk, Adult, Antibodies, Viral, Antigens, Viral, Coronavirus Nucleocapsid Proteins, Female, Humans, Milk, Human, Protein Binding, Protein Domains, Spike Glycoprotein, Coronavirus

Journal Title

Emerg Microbes Infect

Conference Name

Journal ISSN

2222-1751
2222-1751

Volume Title

9

Publisher

Informa UK Limited