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Updates on the hematologic tumor microenvironment and its therapeutic targeting.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Forte, Dorian 
Krause, Daniela S 
Andreeff, Michael 
Bonnet, Dominique 
Méndez-Ferrer, Simón  ORCID logo  https://orcid.org/0000-0002-9805-9988

Abstract

In this review article, we present recent updates on the hematologic tumor microenvironment following the 3rd Scientific Workshop on the Haematological Tumour Microenvironment and its Therapeutic Targeting organized by the European School of Hematology, which took place at the Francis Crick Institute in London in February 2019. This review article is focused on recent scientific advances highlighted in the invited presentations at the meeting, which encompassed the normal and malignant niches supporting hematopoietic stem cells and their progeny. Given the precise focus, it does not discuss other relevant contributions in this field, which have been the scope of other recent reviews. The content covers basic research and possible clinical applications with the major therapeutic angle of utilizing basic knowledge to devise new strategies to target the tumor microenvironment in hematologic cancers. The review is structured in the following sections: (i) regulation of normal hematopoietic stem cell niches during development, adulthood and aging; (ii) metabolic adaptation and reprogramming in the tumor microenvironment; (iii) the key role of inflammation in reshaping the normal microenvironment and driving hematopoietic stem cell proliferation; (iv) current understanding of the tumor microenvironment in different malignancies, such as chronic lymphocytic leukemia, multiple myeloma, acute myeloid leukemia and myelodysplastic syndromes; and (v) the effects of therapies on the microenvironment and some opportunities to target the niche directly in order to improve current treatments.

Description

Keywords

Hematologic Neoplasms, Hematopoiesis, Hematopoietic Stem Cells, Humans, Tumor Microenvironment

Journal Title

Haematologica

Conference Name

Journal ISSN

0390-6078
1592-8721

Volume Title

104

Publisher

Ferrata Storti Foundation (Haematologica)
Sponsorship
European Research Council (648765)
Italian Association for Cancer Research (AIRC) (Fellowship Rif. 20930)
Medical Research Council (MC_PC_12009)
Cancer Research UK (26670)