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Prevalence of SARS-CoV-2 antibodies in healthy blood donors from the state of Tyrol, Austria, in summer 2020.

cam.issuedOnline2021-10-26
dc.contributor.authorSiller, Anita
dc.contributor.authorWachter, Gregor A
dc.contributor.authorNeururer, Sabrina
dc.contributor.authorPfeifer, Bernhard
dc.contributor.authorAstl, Manfred
dc.contributor.authorBorena, Wegene
dc.contributor.authorKimpel, Janine
dc.contributor.authorElmer, Sebastian
dc.contributor.authorSpöck, Franziska
dc.contributor.authorVales, Anja
dc.contributor.authorMühlbacher, Annelies
dc.contributor.authorGaber, Manfred
dc.contributor.authorWilleit, Peter
dc.contributor.authorSchennach, Harald
dc.contributor.orcidWilleit, Peter [0000-0002-1866-7159]
dc.date.accessioned2022-01-06T11:52:24Z
dc.date.available2022-01-06T11:52:24Z
dc.date.issued2021-12
dc.date.updated2022-01-06T11:52:23Z
dc.description.abstractBACKGROUND: Seroepidemiological studies provide important insight into the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) in our society. We aimed to determine seropositivity of SARS-CoV‑2 antibodies and its cross-sectional correlates in a large cohort of blood donors. METHODS: In this observational cohort study, we tested healthy blood donors residing in Tyrol, Austria, for SARS-CoV‑2 antibodies using the Abbott SARS-CoV‑2 IgG chemiluminescent microparticle immunoassay. We estimated 95% confidence intervals (95% CI) of seroprevalences using bootstrapping and tested for differences by participant characteristics using logistic regression. FINDINGS: Between 8 June and 4 September 2020, we screened 5345 healthy individuals at local blood donor sessions (mean age 42.7 years, SD 13.5 years, 46.7% female). Overall seroprevalence was 3.1% (95% CI 2.7-3.6%, 165 cases), which is 5.1-fold higher (95% CI 4.5-6.0%) than the case number identified by the health authorities in the state-wide testing program (0.6%; 4536 out of 757,634). Seroprevalence was higher in the district Landeck (16.6%, P < 0.001) and in individuals aged < 25 years (4.7%, P = 0.043), but did not differ by gender, blood types, or medication intake. The odds ratio for seropositivity was 2.51 for participants who had travelled to Ischgl (1.49-4.21, P = 0.001), 1.39 who had travelled to other federal states (1.00-1.93, P = 0.052), and 2.41 who had travelled abroad (1.61-3.63, P < 0.001). Compared to participants who had a suspected/confirmed SARS-CoV‑2 infection but were seronegative, seropositive participants more frequently reported loss of smell (odds ratio = 2.49, 1.32-4.68, P = 0.005) and taste (odds ratio = 2.76, 1.54-4.92, P = 0.001). CONCLUSION: In summer 2020, SARS-CoV‑2 seroprevalence in Tyrolean blood donors was 3.1%. Our study revealed regional variation and associations with young age, travel history and specific symptoms.
dc.identifier.doi10.17863/CAM.79627
dc.identifier.eissn1613-7671
dc.identifier.issn0043-5325
dc.identifier.otherPMC8546400
dc.identifier.other34698961
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332181
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1007/s00508-021-01963-3
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 1613-7671
dc.sourcenlmid: 21620870R
dc.subjectCovid-19
dc.subjectCross-sectional studies
dc.subjectEpidemiology
dc.subjectSeropositivity
dc.subjectSeroprevalence
dc.subjectAdult
dc.subjectAntibodies, Viral
dc.subjectAustria
dc.subjectBlood Donors
dc.subjectCOVID-19
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectPrevalence
dc.subjectSARS-CoV-2
dc.subjectSeroepidemiologic Studies
dc.titlePrevalence of SARS-CoV-2 antibodies in healthy blood donors from the state of Tyrol, Austria, in summer 2020.
dc.typeArticle
dcterms.dateAccepted2021-09-28
prism.publicationNameWien Klin Wochenschr
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1007/s00508-021-01963-3

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