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In Vitro Models for Investigating Intestinal Host-Pathogen Interactions.

Published version
Peer-reviewed

Repository DOI


Change log

Authors

Oldroyd, Sophie 
Yang, Woojin 
Wang, Kaixin 
Hoven, Darius 

Abstract

Infectious diseases are increasingly recognized as a major threat worldwide due to the rise of antimicrobial resistance and the emergence of novel pathogens. In vitro models that can adequately mimic in vivo gastrointestinal physiology are in high demand to elucidate mechanisms behind pathogen infectivity, and to aid the design of effective preventive and therapeutic interventions. There exists a trade-off between simple and high throughput models and those that are more complex and physiologically relevant. The complexity of the model used shall be guided by the biological question to be addressed. This review provides an overview of the structure and function of the intestine and the models that are developed to emulate this. Conventional models are discussed in addition to emerging models which employ engineering principles to equip them with necessary advanced monitoring capabilities for intestinal host-pathogen interrogation. Limitations of current models and future perspectives on the field are presented.

Description

Publication status: Published

Keywords

gut microbiome, in vitro models, organoids, pathogens, tissue engineering, Organoids, Intestines, Host-Pathogen Interactions

Journal Title

Adv Sci (Weinh)

Conference Name

Journal ISSN

2198-3844
2198-3844

Volume Title

Publisher

Wiley
Sponsorship
Engineering and Physical Sciences Research Council (EP/S022953/1)
EPSRC (EP/S023046/1)
United States Air Force (FA86552017021)