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Datasets of in vitro clonogenic assays showing low dose hyper-radiosensitivity and induced radioresistance.

Published version
Peer-reviewed

Type

Article

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Authors

Polgár, Szabolcs 

Abstract

Low dose hyper-radiosensitivity and induced radioresistance are primarily observed in surviving fractions of cell populations exposed to ionizing radiation, plotted as the function of absorbed dose. Several biophysical models have been developed to quantitatively describe these phenomena. However, there is a lack of raw, openly available experimental data to support the development and validation of quantitative models. The aim of this study was to set up a database of experimental data from the public literature. Using Google Scholar search, 46 publications with 101 datasets on the dose-dependence of surviving fractions, with clear evidence of low dose hyper-radiosensitivity, were identified. Surviving fractions, their uncertainties, and the corresponding absorbed doses were digitized from graphs of the publications. The characteristics of the cell line and the irradiation were also recorded, along with the parameters of the linear-quadratic model and/or the induced repair model if they were provided. The database is available in STOREDB, and can be used for meta-analysis, for comparison with new experiments, and for development and validation of biophysical models.

Description

Keywords

Animals, Cell Line, Cell Survival, Databases, Factual, Dose-Response Relationship, Radiation, Humans, Linear Models, Radiation Tolerance

Journal Title

Sci Data

Conference Name

Journal ISSN

2052-4463
2052-4463

Volume Title

9

Publisher

Springer Science and Business Media LLC
Sponsorship
European Commission (900009)
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