Strategy for Controlled Protection of Redox-Cycling Ortho-Quinones with Self-Immolative Linkers

Strategy for Controlled Protection of Redox-Cycling Ortho-Quinones with Self-Immolative Linkers

Repository URI

https://www.repository.cam.ac.uk/handle/1810/325041

Repository DOI

https://doi.org/10.17863/CAM.72496

Type

Authors

Dunsmore, Lavinia

https://orcid.org/0000-0002-9125-6081

Abstract

[Restricted]

Date

2021-01-29

Advisors

Bernardes, Gonçalo

Keywords

ortho-quinone, quinone, lapachone, beta-lapachone, prodrug, self-immolative linker, pH dependence, para-aminobenzyl ketol, para-hydroxybenzyl ketol, redox, redox cycling, antibody-drug conjugate, ADC, targeted therapy, acute myeloid leukaemia

Qualification

Doctor of Philosophy (PhD)

Awarding Institution

University of Cambridge

Rights and licensing

All Rights Reserved

Except where otherwised noted, this item's license is described as All Rights Reserved

Sponsorship

Biotechnology and Biological Sciences Research Council (1795534)

UKRI BBSRC DTP PhD Studentship (1795534)

Collections

Theses - Chemistry