Strategy for Controlled Protection of Redox-Cycling Ortho-Quinones with Self-Immolative Linkers
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Type
Thesis
Change log
Authors
Abstract
[Restricted]
Description
Date
2021-01-29
Advisors
Bernardes, Gonçalo
Keywords
ortho-quinone, quinone, lapachone, beta-lapachone, prodrug, self-immolative linker, pH dependence, para-aminobenzyl ketol, para-hydroxybenzyl ketol, redox, redox cycling, antibody-drug conjugate, ADC, targeted therapy, acute myeloid leukaemia
Qualification
Doctor of Philosophy (PhD)
Awarding Institution
University of Cambridge
Rights
Sponsorship
Biotechnology and Biological Sciences Research Council (1795534)
UKRI BBSRC DTP PhD Studentship (1795534)