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The complexity of biological control systems: An autophagy case study.
| cam.depositDate | 2022-01-06 | |
| cam.issuedOnline | 2022-01-14 | |
| cam.orpheus.success | Tue Feb 01 19:02:37 GMT 2022 - Embargo updated | |
| datacite.ispreviousversionof.handle | https://www.repository.cam.ac.uk/handle/1810/334371 | |
| dc.contributor.author | Pavel, Mariana | |
| dc.contributor.author | Tanasa, Radu | |
| dc.contributor.author | Park, Sojung | |
| dc.contributor.author | Rubinsztein, David | |
| dc.contributor.orcid | Rubinsztein, David [0000-0001-5002-5263] | |
| dc.date.accessioned | 2022-01-07T00:31:14Z | |
| dc.date.available | 2022-01-07T00:31:14Z | |
| dc.date.issued | 2022-01-14 | |
| dc.date.updated | 2022-01-06T09:09:32Z | |
| dc.description.abstract | Autophagy and YAP1-WWTR1/TAZ signalling are tightly linked in a complex control system of forward and feedback pathways which determine different cellular outcomes in differing cell types at different time-points after perturbations. Here we extend our previous experimental and modelling approaches to consider two possibilities. First, we have performed additional mathematical modelling to explore how the autophagy-YAP1 crosstalk may be controlled by posttranslational modifications of components of the pathways. Second, since analogous contrasting results have also been reported for autophagy as a regulator of other transduction pathways engaged in tumorigenesis (Wnt/β-catenin, TGF-β/Smads, NF-kB or XIAP/cIAPs), we have considered if such discrepancies may be explicable through situations involving competing pathways and feedback loops in different cell types, analogous to the autophagy-YAP/TAZ situation. Since distinct posttranslational modifications dominate those pathways in distinct cells, these need to be understood to enable appropriate cell type-specific therapeutic strategies for cancers and other diseases. | |
| dc.description.sponsorship | We are grateful for funding from the UK Dementia Research Institute (funded by MRC, Alzheimer’s Research UK and the Alzheimer’s Society), a grant of the Romanian Ministry of Research, Innovation and Digitization, CNCS/CCCDI-UEFISCDI, project number PN-III-P1-1.1-PD-2019-0733, within PNCDI-III, and POC/448/1/1/127606 CENEMED project (M.P.). | |
| dc.identifier.doi | 10.17863/CAM.79700 | |
| dc.identifier.eissn | 1521-1878 | |
| dc.identifier.issn | 0265-9247 | |
| dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/332255 | |
| dc.language.iso | eng | |
| dc.publisher | Wiley | |
| dc.publisher.department | Department of Medical Genetics | |
| dc.rights | All Rights Reserved | |
| dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
| dc.title | The complexity of biological control systems: An autophagy case study. | |
| dc.type | Article | |
| dcterms.dateAccepted | 2022-01-04 | |
| prism.publicationName | Bioessays | |
| pubs.licence-display-name | Apollo Repository Deposit Licence Agreement | |
| pubs.licence-identifier | apollo-deposit-licence-2-1 | |
| rioxxterms.type | Journal Article/Review | |
| rioxxterms.version | AM | |
| rioxxterms.versionofrecord | 10.1002/bies.202100224 |
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