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Mapping diversity in African trypanosomes using high resolution spatial proteomics.

Published version
Peer-reviewed

Repository DOI


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Abstract

African trypanosomes are dixenous eukaryotic parasites that impose a significant human and veterinary disease burden on sub-Saharan Africa. Diversity between species and life-cycle stages is concomitant with distinct host and tissue tropisms within this group. Here, the spatial proteomes of two African trypanosome species, Trypanosoma brucei and Trypanosoma congolense, are mapped across two life-stages. The four resulting datasets provide evidence of expression of approximately 5500 proteins per cell-type. Over 2500 proteins per cell-type are classified to specific subcellular compartments, providing four comprehensive spatial proteomes. Comparative analysis reveals key routes of parasitic adaptation to different biological niches and provides insight into the molecular basis for diversity within and between these pathogen species.

Description

Funder: Isaac Newton Trust, Wellcome Trust, University of Cambridge Joint Research Grant


Funder: Dutch Science Organisation (VI.Veni.202.223)

Keywords

Humans, Animals, Trypanosomiasis, African, Tsetse Flies, Proteome, Proteomics, Trypanosoma brucei brucei, Trypanosoma congolense

Journal Title

Nat Commun

Conference Name

Journal ISSN

2041-1723
2041-1723

Volume Title

14

Publisher

Springer Science and Business Media LLC
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/P010849/1)
Wellcome Trust (214298/Z/18/Z)