Elucidating the genetic basis of social interaction and isolation.


Type
Article
Change log
Authors
Perry, John RB 
Abstract

The negative impacts of social isolation and loneliness on health are well documented. However, little is known about their possible biological determinants. In up to 452,302 UK Biobank study participants, we perform genome-wide association study analyses for loneliness and regular participation in social activities. We identify 15 genomic loci (P < 5 × 10-8) for loneliness, and demonstrate a likely causal association between adiposity and increased susceptibility to loneliness and depressive symptoms. Further loci were identified for regular attendance at a sports club or gym (N = 6 loci), pub or social club (N = 13) or religious group (N = 18). Across these traits there was strong enrichment for genes expressed in brain regions that control emotional expression and behaviour. We demonstrate aetiological mechanisms specific to each trait, in addition to identifying loci that are pleiotropic across multiple complex traits. Further study of these traits may identify novel modifiable risk factors associated with social withdrawal and isolation.

Description
Keywords
Adult, Depression, Female, Genome, Human, Genome-Wide Association Study, Genomics, Humans, Interpersonal Relations, Loneliness, Male, Polymorphism, Single Nucleotide, Risk Factors
Journal Title
Nat Commun
Conference Name
Journal ISSN
2041-1723
2041-1723
Volume Title
9
Publisher
Springer Science and Business Media LLC
Sponsorship
Medical Research Council (MC_UU_12015/2)