This is the user's manual of MC@NLO 2.2. This package is a practical implementation, based upon the HERWIG event generator, of the MC@NLO formalism, which allows one to incorporate NLO QCD matrix elements consistently into a parton shower framework. Processes available in this version include the hadroproduction of Higgs bosons, single vector bosons, vector boson pairs, and heavy quark-antiquark pairs. This document is self-contained, but we emphasise the main differences with respect to previous versions.