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Validation of IBD-associated Whole-blood DNA Methylation Changes-Where Do We Go From Here?

Accepted version
Peer-reviewed

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Type

Article

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Authors

Ross, Alexander DB 

Abstract

Epigenetic states are potentially reversible modifications of the genetic structure that represent the interface between genetic and environmental factors. A likely association between the rising incidences of the inflammatory bowel diseases [IBD] (Crohn’s disease [CD] and ulcerative colitis [UC]) and distinct environmental changes occurring in recent decades implicate epigenetic mechanisms in the pathogenesis of these complex, multifactorial conditions.1 DNA methylation [DNAm] is an assayable and dynamic yet relatively stable epigenetic mechanism, making it an attractive target for the development of diagnostic/prognostic biomarkers.2 Furthermore, cell-type specific IBD-associated DNAm changes may lead to stable alterations in cellular function and thereby contribute to chronic intestinal inflammation. However, despite the plausible concept of epigenetics in IBD pathogenesis, the field is still lacking convincing evidence in support of the key hypothesis. Furthermore, the promise of delivering reliable clinical markers that could lead to a more personalised treatment approach, has yet to be fulfilled.

Description

Keywords

Humans, DNA Methylation, Epigenome, Inflammatory Bowel Diseases, Colitis, Ulcerative, Epigenesis, Genetic

Journal Title

J Crohns Colitis

Conference Name

Journal ISSN

1873-9946
1876-4479

Volume Title

Publisher

Oxford University Press (OUP)
Sponsorship
MRC (MR/T001917/1)