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No association of a Vascular endothelial growth factor A (VEGFA) gene polymorphism with pre-eclampsia among pregnant women in Uganda.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Nabweyambo, Sheila 
Kanyerezi, Stephen 
Petterson, John H-O 
Katabazi, Fred Ashaba 
Ssekagiri, Alfred 

Abstract

BACKGROUND: Vascular endothelial growth factor A (VEGFA) is a major angiogenic factor that plays an important role in the formation of blood vessels during embryonic development. VEGFA has been implicated in the pathophysiology of pre-eclampsia (PE), since pre-eclamptic women present with reduced levels of free circulating VEGFA. The 3' untranslated region (3'-UTR) of the VEGFA gene consists of elements that regulate the transcription and hence expression of the VEGFA protein in circulation. Hence it is suggested that variations thereof could underlie the reduced VEGFA levels observed in pre-eclamptic women. The purpose of this study was to investigate presence of the + 936C/T polymorphism, a common single nucleotide polymorphism (SNP) in the 3'-UTR of the VEGFA gene, and determine its association with PE among pregnant women in Uganda. RESULTS: There was no significant difference observed in the allele and genotype frequencies of the + 936C/T 3' UTR-VEGFA polymorphism between pre-eclamptic and normotensive pregnant women (P > 0.05). Additionally, there was no significant difference in the median plasma levels of free VEGFA among women with the wild type, CT and TT genotypes of the + 936C/T VEGFA polymorphism (median = 0.84 pg/mL (IQR = 0.39-1.41) Vs 1.05 (0.61-1.18) Vs 1.05 (1.05-1.05) respectively, p-value = 0.7161). CONCLUSIONS: These study findings indicate that the + 936C/T 3' UTR-VEGFA polymorphism had no significant association with increased susceptibility to PE among women in Uganda. Further studies with a larger sample size are recommended.

Description

Keywords

3’ Untranslated region, Africa, Genetic biomarkers, Genetic variations, Pre-eclampsia, Sanger sequencing, Single nucleotide polymorphism, Uganda, Vascular endothelial growth factor, Humans, Female, Pregnancy, Pre-Eclampsia, Pregnant Women, Vascular Endothelial Growth Factor A, 3' Untranslated Regions, Uganda, Genotype, Polymorphism, Single Nucleotide, Case-Control Studies, Genetic Predisposition to Disease

Journal Title

BMC Genomics

Conference Name

Journal ISSN

1471-2164
1471-2164

Volume Title

24

Publisher

Springer Science and Business Media LLC