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Data-driven approaches to reveal the pathobiological heterogeneity in patients with traumatic brain injury.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Ercole, Ari 

Abstract

In traumatic brain injury (TBI), the inability of Glasgow Coma Scale (GCS) to capture the inherent heterogeneity of the disease may provide some explanation as to why randomised trials of biologically plausible therapies have largely failed. Such considerations provide strong motivation for the development of precision medicine approaches in this domain to improve outcome.3–5 Subgroups of patients with distinct pathophysiological or pathobiological mechanisms - so called endotypes - can be sought as a step to identifying individualised treatments. This can be done by data-driven approaches such as using unsupervised clustering algorithms.

Description

Keywords

32 Biomedical and Clinical Sciences, 3202 Clinical Sciences, 3 Good Health and Well Being

Journal Title

Intensive Care Med

Conference Name

Journal ISSN

0342-4642
1432-1238

Volume Title

Publisher

Springer Science and Business Media LLC