Mechanisms of Non-canonical Activation of Ataxia Telangiectasia Mutated.


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Type
Article
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Authors
Khoronenkova, SV 
Abstract

ATM is a master regulator of the cellular response to DNA damage. The classical mechanism of ATM activation involves its monomerization in response to DNA double-strand breaks, resulting in ATM-dependent phosphorylation of more than a thousand substrates required for cell cycle progression, DNA repair, and apoptosis. Here, new experimental evidence for non-canonical mechanisms of ATM activation in response to stimuli distinct from DNA double-strand breaks is discussed. It includes cytoskeletal changes, chromatin modifications, RNA-DNA hybrids, and DNA single-strand breaks. Noncanonical ATM activation may be important for the pathology of the multisystemic disease Ataxia Telangiectasia.

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Keywords
Animals, Ataxia Telangiectasia, Ataxia Telangiectasia Mutated Proteins, DNA, DNA Repair, DNA, Single-Stranded, Enzyme Activation, Humans, RNA
Journal Title
Biochemistry (Mosc)
Conference Name
Journal ISSN
0006-2979
1608-3040
Volume Title
81
Publisher
Pleiades Publishing Ltd