The elastic moduli and acoustic loss behaviour of Ti-6Al-4V (wt.%) in the temperature range 5–298 K have been studied using Resonant Ultrasound Spectroscopy. A peak in the acoustic dissipation was observed at 160 K within the frequency range 250–1000 kHz. Analysis of the data acquired in this study, coupled with complementary data from the literature, showed that this was consistent with a Snoek-like relaxation process with an associated activation energy of 23 3 kJ mol$\mathrm{<mrow\; data-mjx-texclass="ORD">-1</mrow>}$. However, the loss peak was broader than would be expected for a Snoek-like relaxation, and the underlying process was shown to have a spread of relaxation times. It is suggested that this effect arises as a result of variations in the strain experienced by the β phase due to different local microstructural constraint by the bounding secondary α phase.