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Regional disparity in continuously measured time-domain cerebrovascular reactivity indices: a scoping review of human literature.

Published version
Peer-reviewed

Repository DOI


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Authors

Sainbhi, Amanjyot Singh  ORCID logo  https://orcid.org/0000-0003-3231-5683
Marquez, Izabella 
Stein, Kevin Y 
Amenta, Fiorella 

Abstract

Objective: Cerebral blood vessels maintaining relatively constant cerebral blood flow (CBF) over wide range of systemic arterial blood pressure (ABP) is referred to as cerebral autoregulation (CA). Impairments in CA expose the brain to pressure-passive flow states leading to hypoperfusion and hyperperfusion. Cerebrovascular reactivity (CVR) metrics refer to surrogate metrics of pressure-based CA that evaluate the relationship between slow vasogenic fluctuations in cerebral perfusion pressure/ABP and a surrogate for pulsatile CBF/cerebral blood volume.Approach: We performed a systematically conducted scoping review of all available human literature examining the association between continuous CVR between more than one brain region/channel using the same CVR index.Main Results: In all the included 22 articles, only handful of transcranial doppler (TCD) and near-infrared spectroscopy (NIRS) based metrics were calculated for only two brain regions/channels. These metrics found no difference between left and right sides in healthy volunteer, cardiac surgery, and intracranial hemorrhage patient studies. In contrast, significant differences were reported in endarterectomy, and subarachnoid hemorrhage studies, while varying results were found regarding regional disparity in stroke, traumatic brain injury, and multiple population studies.Significance: Further research is required to evaluate regional disparity using NIRS-based indices and to understand if NIRS-based indices provide better regional disparity information than TCD-based indices.

Description

Funder: Manitoba Public Insurance (MPI) Professorship in Neuroscience

Keywords

NIRS-based indices, TCD-based indices, cerebral autoregulation, cerebrovascular reactivity metrics, regional disparity, time-domain metrics, Humans, Brain Injuries, Traumatic, Arterial Pressure, Brain, Cerebrovascular Circulation, Subarachnoid Hemorrhage, Ultrasonography, Doppler, Transcranial

Journal Title

Physiol Meas

Conference Name

Journal ISSN

0967-3334
1361-6579

Volume Title

44

Publisher

IOP Publishing
Sponsorship
Natural Sciences and Engineering Research Council of Canada (ALLRP-576386-22, ALLRP-578524-22, DGECR-2022-00260, RGPIN-2022-03621)