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Benign preparation of aqueous core poly lactic-co-glycolic acid (PLGA) microcapsules.

Accepted version
Peer-reviewed

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Authors

Nomura, Toshiyuki 
Routh, Alexander F 

Abstract

Poly lactic-co-glycolic acid (PLGA) has attracted considerable attention as a polymer for drug delivery carriers. However, the hydrophobic property of PLGA often leads to the use of harmful organic solvents and poor encapsulation efficiency of hydrophilic materials. To our knowledge, a preparation method of aqueous core PLGA microcapsules without using harmful organic solvents has not been proposed. In this study, we attempted to establish an encapsulation technique of hydrophilic materials in aqueous core biodegradable and biocompatible PLGA microcapsules using vegetable oil as a continuous phase. As a result, the temperature of the oil/water mixture was required to be above the glass transition temperature. In this condition, two different types of morphology were prepared. When the water volume was below the solubility limit, PLGA microcapsules with a smooth shell were formed. In contrast, when the water volume was above the solubility limit, colloidosome-like microcapsules with PLGA nanoparticles assembled at the interface were formed. The obtained microcapsules were then heated at the glass transition temperature. The result is that aqueous core PLGA microcapsules with a smooth shell were prepared using plant oil as a continuous phase. Rhodamine B used as a hydrophilic model encapsulant, was successfully encapsulated in the PLGA microcapsules.

Description

Keywords

Hydrophilic encapsulant, Microcapsules, Poly lactic-co-glycolic acid, Vegetable oil, Capsules, Drug Carriers, Emulsions, Lactic Acid, Microspheres, Polyglycolic Acid, Polylactic Acid-Polyglycolic Acid Copolymer, Rhodamines, Solvents

Journal Title

J Colloid Interface Sci

Conference Name

Journal ISSN

0021-9797
1095-7103

Volume Title

513

Publisher

Elsevier BV