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Slc20a2, Encoding the Phosphate Transporter PiT2, Is an Important Genetic Determinant of Bone Quality and Strength.

Published version
Peer-reviewed

Type

Conference Object

Change log

Authors

Beck-Cormier, Sarah 
Lelliott, Christopher J 
Logan, John G 
Lafont, David T 
Merametdjian, Laure 

Abstract

Osteoporosis is characterized by low bone mineral density (BMD) and fragility fracture and affects over 200 million people worldwide. Bone quality describes the material properties that contribute to strength independently of BMD, and its quantitative analysis is a major priority in osteoporosis research. Tissue mineralization is a fundamental process requiring calcium and phosphate transporters. Here we identify impaired bone quality and strength in Slc20a2-/- mice lacking the phosphate transporter SLC20A2. Juveniles had abnormal endochondral and intramembranous ossification, decreased mineral accrual, and short stature. Adults exhibited only small reductions in bone mass and mineralization but a profound impairment of bone strength. Bone quality was severely impaired in Slc20a2-/- mice: yield load (-2.3 SD), maximum load (-1.7 SD), and stiffness (-2.7 SD) were all below values predicted from their bone mineral content as determined in a cohort of 320 wild-type controls. These studies identify Slc20a2 as a physiological regulator of tissue mineralization and highlight its critical role in the determination of bone quality and strength. © 2019 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc.

Description

Keywords

ANIMAL MODELS (GENETIC ANIMAL MODELS), BONE MATRIX (MATRIX MINERALIZATION), DISORDERS OF CALCIUM/PHOSPHATE METABOLISM (OTHER), GENETIC RESEARCH (HUMAN ASSOCIATION STUDIES), ORTHOPAEDICS (BIOMECHANICS), Animals, Animals, Newborn, Bone Development, Bone Resorption, Bone and Bones, Calcification, Physiologic, Calcinosis, Cells, Cultured, Chondrocytes, Humans, Incisor, Mice, Inbred C57BL, Mice, Knockout, Osteoblasts, Phenotype, Skull, Sodium-Phosphate Cotransporter Proteins, Type III, Tooth, X-Ray Microtomography

Journal Title

J Bone Miner Res

Conference Name

Journal ISSN

0884-0431
1523-4681

Volume Title

34

Publisher

Oxford University Press (OUP)