Repository logo
 

Disrupted habenula function in major depression.

Simple item page
cam.issuedOnline2016-05-31
dc.contributor.authorLawson, RP
dc.contributor.authorNord, CL
dc.contributor.authorSeymour, B
dc.contributor.authorThomas, DL
dc.contributor.authorDayan, P
dc.contributor.authorPilling, S
dc.contributor.authorRoiser, JP
dc.contributor.orcidSeymour, B [0000-0003-1724-5832]
dc.date.accessioned2018-11-07T00:30:28Z
dc.date.available2018-11-07T00:30:28Z
dc.date.issued2017-02
dc.description.abstractThe habenula is a small, evolutionarily conserved brain structure that plays a central role in aversive processing and is hypothesised to be hyperactive in depression, contributing to the generation of symptoms such as anhedonia. However, habenula responses during aversive processing have yet to be reported in individuals with major depressive disorder (MDD). Unmedicated and currently depressed MDD patients (N=25, aged 18-52 years) and healthy volunteers (N=25, aged 19-52 years) completed a passive (Pavlovian) conditioning task with appetitive (monetary gain) and aversive (monetary loss and electric shock) outcomes during high-resolution functional magnetic resonance imaging; data were analysed using computational modelling. Arterial spin labelling was used to index resting-state perfusion and high-resolution anatomical images were used to assess habenula volume. In healthy volunteers, habenula activation increased as conditioned stimuli (CSs) became more strongly associated with electric shocks. This pattern was significantly different in MDD subjects, for whom habenula activation decreased significantly with increasing association between CSs and electric shocks. Individual differences in habenula volume were negatively associated with symptoms of anhedonia across both groups. MDD subjects exhibited abnormal negative task-related (phasic) habenula responses during primary aversive conditioning. The direction of this effect is opposite to that predicted by contemporary theoretical accounts of depression based on findings in animal models. We speculate that the negative habenula responses we observed may result in the loss of the capacity to actively avoid negative cues in MDD, which could lead to excessive negative focus.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.32054
dc.identifier.eissn1476-5578
dc.identifier.issn1359-4184
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284681
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1038/mp.2016.81
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAffect
dc.subjectAnhedonia
dc.subjectCase-Control Studies
dc.subjectComputer Simulation
dc.subjectConditioning, Classical
dc.subjectCues
dc.subjectDepression
dc.subjectDepressive Disorder, Major
dc.subjectFemale
dc.subjectHabenula
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectStructure-Activity Relationship
dc.titleDisrupted habenula function in major depression.
dc.typeArticle
dcterms.dateAccepted2016-04-11
prism.endingPage208
prism.issueIdentifier2
prism.publicationDate2017
prism.publicationNameMol Psychiatry
prism.startingPage202
prism.volume22
rioxxterms.licenseref.startdate2017-02
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/mp.2016.81

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Disrupted habenula function in major depression.pdf
Size:
280.63 KB
Format:
Adobe Portable Document Format
Description:
Published version
Licence
https://creativecommons.org/licenses/by/4.0/
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
DepositLicenceAgreement.pdf
Size:
417.78 KB
Format:
Adobe Portable Document Format
Download

Collections

Cambridge University Research Outputs