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The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris.

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cam.issuedOnline2021-10-08
dc.contributor.authorHsueh, Tun-Pin
dc.contributor.authorLin, Wan-Ling
dc.contributor.authorDalley, Jeffrey W
dc.contributor.authorTsai, Tung-Hu
dc.contributor.orcidHsueh, Tun-Pin [0000-0002-0107-7961]
dc.contributor.orcidDalley, Jeffrey W [0000-0002-2282-3660]
dc.contributor.orcidTsai, Tung-Hu [0000-0002-9007-2547]
dc.date.accessioned2022-01-05T16:34:10Z
dc.date.available2022-01-05T16:34:10Z
dc.date.issued2021-10-08
dc.date.updated2022-01-05T16:34:09Z
dc.description.abstractArtemisia capillaris Thunb. (A.capillaris, Yin-Chen in Chinese) is a traditional medicinal herb with a wide spectrum of pharmacological properties ranging from effects against liver dysfunction to treatments of severe cirrhosis and cancer. We used relevant keywords to search electronic databases, including PubMed, Medline, and Google Scholar, for scientific contributions related to this medicinal herb and the pharmacokinetics of its components. The pharmaceutical effects of A.capillaris contribute to the treatment not only of viral hepatitis, cirrhosis, and hepatocellular hepatoma, but also metabolic syndrome, psoriasis, and enterovirus in the clinic. The bioactive compounds, including scoparone, capillarisin, scopoletin, and chlorogenic acid, exhibit antioxidant, anti-inflammatory, antisteatotic, antiviral, and antitumor properties, reflecting the pharmacological effects of A.capillaris. The pharmacokinetics of the main bioactive compounds in A. capillaris can achieve a maximum concentration within 1 hour, but only chlorogenic acid has a relatively long half-life. Regarding the use of the A. capillaris herb by health professionals to treat various diseases, the dosing schedule of this herb should be carefully considered to maximize therapeutic outcomes while lessening possible side effects.
dc.identifier.doi10.17863/CAM.79542
dc.identifier.eissn2227-9059
dc.identifier.issn2227-9059
dc.identifier.otherPMC8533588
dc.identifier.other34680529
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332095
dc.languageeng
dc.language.isoeng
dc.publisherMDPI AG
dc.publisher.urlhttp://dx.doi.org/10.3390/biomedicines9101412
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2227-9059
dc.sourcenlmid: 101691304
dc.subjectArtemisia
dc.subjectYin-Chen
dc.subjectherbal medicine
dc.subjectpharmacokinetics
dc.subjectpharmacology
dc.subjectscoparone
dc.titleThe Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris.
dc.typeArticle
dcterms.dateAccepted2021-09-28
prism.issueIdentifier10
prism.publicationNameBiomedicines
prism.volume9
pubs.funder-project-idMinistry of Science and Technology of Taiwan (MOST 109-2113-M-010-007)
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.3390/biomedicines9101412

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