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Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Fachal, Laura 
Beesley, Jonathan 
Allen, Jamie 

Abstract

Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the set of credible causal variants in each one. In parallel, we used a Bayesian approach (PAINTOR) that combines genetic association, linkage disequilibrium and enriched genomic features to determine variants with high posterior probabilities of being causal. Potentially causal variants were significantly over-represented in active gene regulatory regions and transcription factor binding sites. We applied our INQUSIT pipeline for prioritizing genes as targets of those potentially causal variants, using gene expression (expression quantitative trait loci), chromatin interaction and functional annotations. Known cancer drivers, transcription factors and genes in the developmental, apoptosis, immune system and DNA integrity checkpoint gene ontology pathways were over-represented among the highest-confidence target genes.

Description

Keywords

Bayes Theorem, Biomarkers, Tumor, Breast Neoplasms, Chromosome Mapping, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Regulatory Sequences, Nucleic Acid, Risk Factors

Journal Title

Nat Genet

Conference Name

Journal ISSN

1061-4036
1546-1718

Volume Title

52

Publisher

Springer Science and Business Media LLC
Sponsorship
Cancer Research Uk (None)
European Commission Horizon 2020 (H2020) Societal Challenges (634935)
European Commission Horizon 2020 (H2020) Societal Challenges (633784)
European Commission (223175)
National Cancer Institute (U19CA148065)
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (656144)
Cancer Research UK (10710)
Cancer Research UK (16563)
Cancer Research UK (10118)
Wellcome Trust (203477/Z/16/Z)
Cancer Research UK (20861)
Cancer Research UK (23382)
Cancer Research UK (16565)
Cancer Research UK (20411)
Includes CRUK, FP7 and H2020
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