Repository logo
 

Mating-driven variability in olfactory local interneuron wiring.

Published version
Peer-reviewed

Type

Article

Change log

Abstract

Variations in neuronal connectivity occur widely in nervous systems from invertebrates to mammals. Yet, it is unclear how neuronal variability originates, to what extent and at what time scales it exists, and what functional consequences it might carry. To assess inter- and intraindividual neuronal variability, it would be ideal to analyze the same identified neuron across different brain hemispheres and individuals. Here, using genetic labeling and electron microscopy connectomics, we show that an identified inhibitory olfactory local interneuron, TC-LN, exhibits extraordinary variability in its glomerular innervation patterns. Moreover, TC-LN's innervation of the VL2a glomerulus, which processes food signals and modulates mating behavior, is sexually dimorphic, is influenced by female's courtship experience, and correlates with food intake in mated females. Mating also affects output connectivity of TC-LN to specific local interneurons. We propose that mating-associated variability of TC-LNs regulates how food odor is interpreted by an inhibitory network to modulate feeding.

Description

Keywords

31 Biological Sciences, 32 Biomedical and Clinical Sciences, 3103 Ecology, 5202 Biological Psychology, 3109 Zoology, 3209 Neurosciences, 52 Psychology, Neurosciences, 1.1 Normal biological development and functioning, Neurological

Journal Title

Sci Adv

Conference Name

Journal ISSN

2375-2548
2375-2548

Volume Title

8

Publisher

American Association for the Advancement of Science (AAAS)
Sponsorship
Wellcome Trust (203261/Z/16/Z)