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Single-pixel phase-corrected fiber bundle endomicroscopy with lensless focussing capability.

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Gordon, George SD 
Bohndiek, Sarah E 
Wilkinson, Timothy D 


In this paper a novel single-pixel method for coherent imaging through an endoscopic fiber bundle is presented. The use of a single-pixel detector allows greater sensitivity over a wider range of wavelengths, which could have significant applications in endoscopic fluorescence microscopy. First, the principle of lensless focussing at the distal end of a coherent fiber bundle is simulated to examine the impact of pixelation at microscopic scales. Next, an experimental optical correlator system using spatial light modulators (SLMs) is presented. A simple contrast imaging method of characterizing and compensating phase aberrations introduced by fiber bundles is described. Experimental results are then presented showing that our phase compensation method enables characterization of the optical phase profile of individual fiberlets. After applying this correction, early results demonstrating the ability of the system to electronically adjust the focal plane at the distal end of the fiber bundle are presented. The structural similarity index (SSIM) between the simulated image and the experimental focus-adjusted image increases noticeably when the phase correction is applied and the retrieved image is visually recognizable. Strategies to improve image quality are discussed.



Endoscopes, Holography, Medical diagnostic imaging, Optical fiber applications

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J Lightwave Technol

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Institute of Electrical and Electronics Engineers (IEEE)
Cancer Research Uk (None)
European Commission (630729)
Engineering and Physical Sciences Research Council (EP/I033491/1)
Engineering and Physical Sciences Research Council (EP/J009369/1)
Engineering and Physical Sciences Research Council (EP/M016218/1)
Cancer Research UK (C20/A20976)
G. Gordon would like to acknowledge support from a Henslow Research Fellowship from the Cambridge Philosophical Society, as well as research funding from the Cambridge Cancer Centre and Cancer Research UK. S. Bohndiek would like to acknowledge research funding from a Cancer Research UK Career Establishment Award and the CRUK-EPSRC Cancer Imaging Centre in Cambridge and Manchester.