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How are Trypanosoma brucei receptors protected from host antibody-mediated attack?

Accepted version
Peer-reviewed

Type

Article

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Authors

Minshall, Nicola 
Webb, Helena 
Carrington, Mark 

Abstract

Trypanosoma brucei is the causal agent of African Trypanosomiasis in humans and other animals. It maintains a long-term infection through an antigenic variation based population survival strategy. To proliferate in a mammal, T. brucei acquires iron and haem through the receptor mediated uptake of host transferrin and haptoglobin-haemoglobin respectively. The receptors are exposed to host antibodies but this does not lead to clearance of the infection. Here we discuss how the trypanosome avoids this fate in the context of recent findings on the structure and cell biology of the receptors.

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Keywords

Journal Title

BioEssays

Conference Name

Journal ISSN

0265-9247
1521-1878

Volume Title

46

Publisher

Wiley
Sponsorship
Wellcome Trust (217138/Z/19/Z)