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A hypoxic ticket to the bone metastatic niche.

Published version
Peer-reviewed

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Type

Article

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Abstract

Hypoxia is a well-characterized driver of aggressive cancer phenotypes, including metastasis. Accumulating evidence suggests that, in addition to having local effects, the consequences of tumour hypoxia can be systemic, leading to the formation of pre-metastatic niches that can later foster metastatic colonization in distant organs. Recent findings have demonstrated that such niches can also form in the bone, possibly revealing new avenues for therapeutic intervention.

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Keywords

Bone Neoplasms, Bone and Bones, Breast Neoplasms, Cell Hypoxia, Female, Humans, Neoplasm Metastasis, Tumor Microenvironment

Journal Title

Breast Cancer Res

Conference Name

Journal ISSN

1465-5411
1465-542X

Volume Title

17

Publisher

Springer Science and Business Media LLC
Sponsorship
Medical Research Council (MC_UU_12022/7)