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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.

Published version
Peer-reviewed

Repository DOI


Change log

Authors

Alexander, Stephen PH  ORCID logo  https://orcid.org/0000-0003-4417-497X
Christopoulos, Arthur  ORCID logo  https://orcid.org/0000-0003-4442-3294
Davenport, Anthony P  ORCID logo  https://orcid.org/0000-0002-2096-3117
Kelly, Eamonn 

Abstract

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

Description

Publication status: Published

Keywords

Humans, Databases, Pharmaceutical, Receptors, G-Protein-Coupled, Ligands, Ion Channels, Receptors, Cytoplasmic and Nuclear

Journal Title

Br J Pharmacol

Conference Name

Journal ISSN

0007-1188
1476-5381

Volume Title

180

Publisher

Wiley