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Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region.

Published version
Peer-reviewed

Type

Article

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Authors

Emmenegger, Marc 
De Cecco, Elena 
Lamparter, David 
Jacquat, Raphaël PB 
Riou, Julien 

Abstract

Effective public health measures against SARS-CoV-2 require granular knowledge of population-level immune responses. We developed a Tripartite Automated Blood Immunoassay (TRABI) to assess the IgG response against three SARS-CoV-2 proteins. We used TRABI for continuous seromonitoring of hospital patients and blood donors (n = 72'250) in the canton of Zurich from December 2019 to December 2020 (pre-vaccine period). We found that antibodies waned with a half-life of 75 days, whereas the cumulative incidence rose from 2.3% in June 2020 to 12.2% in mid-December 2020. A follow-up health survey indicated that about 10% of patients infected with wildtype SARS-CoV-2 sustained some symptoms at least twelve months post COVID-19. Crucially, we found no evidence of a difference in long-term complications between those whose infection was symptomatic and those with asymptomatic acute infection. The cohort of asymptomatic SARS-CoV-2-infected subjects represents a resource for the study of chronic and possibly unexpected sequelae.

Description

Keywords

Biological database, Immunology, Microbiology, Virology

Journal Title

iScience

Conference Name

Journal ISSN

2589-0042
2589-0042

Volume Title

26

Publisher

Elsevier BV
Sponsorship
Engineering and Physical Sciences Research Council (EP/L015889/1)