Bacterial RNA chaperones and chaperone-like riboregulators: behind the scenes of RNA-mediated regulation of cellular metabolism.


Type
Article
Change log
Abstract

In all domains of life, RNA chaperones safeguard and guide the fate of the cellular RNA pool. RNA chaperones comprise structurally diverse proteins that ensure proper folding, stability, and ribonuclease resistance of RNA, and they support regulatory activities mediated by RNA. RNA chaperones constitute a topologically diverse group of proteins that often present an unstructured region and bind RNA with limited nucleotide sequence preferences. In bacteria, three main proteins - Hfq, ProQ, and CsrA - have been shown to regulate numerous complex processes, including bacterial growth, stress response and virulence. Hfq and ProQ have well-studied activities as global chaperones with pleiotropic impact, while CsrA has a chaperone-like role with more defined riboregulatory function. Here, we describe relevant novel insights into their common features, including RNA binding properties, unstructured domains, and interplay with other proteins important to RNA metabolism.

Description
Keywords
C-terminal domain, CsrA, Hfq, ProQ, RNA chaperone, RNA metabolism, Riboregulation, Bacteria, Bacterial Proteins, Gene Expression Regulation, Bacterial, Host Factor 1 Protein, Molecular Chaperones, RNA, Bacterial, RNA, Small Untranslated, RNA-Binding Proteins
Journal Title
RNA Biol
Conference Name
Journal ISSN
1547-6286
1555-8584
Volume Title
19
Publisher
Informa UK Limited
Sponsorship
European Commission (101038064)
narodowe centrum nauki (2020/37/K/NZ1/02312, 2020/39/D/NZ1/01651)
Wellcome Trust (200873/Z/16/Z)