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The MesoVATS trial: is there a future for video-assisted thoracoscopic surgery partial pleurectomy?

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Rintoul, Robert C 


Malignant pleural mesothelioma, a uniformly fatal cancer caused by prior asbestos exposure, places a major burden on society. The MesoVATS trial was a multicenter randomized controlled trial that examined the role of video-assisted thoracoscopic partial pleurectomy (VAT-PP) versus talc pleurodesis in patients with malignant pleural mesothelioma. Overall there was no difference in survival between VAT-PP and talc pleurodesis. VAT-PP resulted in more complications, longer hospital stay and was more expensive. However, there was some evidence that VAT-PP improved EQ5D measured quality of life after 6 months particularly in the European Organisation for Research and Treatment of Cancer low-risk subgroup. At present the future role of VAT-PP is uncertain and may merit further investigation but this should be within the context of clinical trials. VAT-PP may also have a role to play in the specific situation of trapped lung.



mesothelioma, partial pleurectomy, video-assisted thoracoscopic surgery, Aged, Clinical Trials as Topic, Female, Humans, Lung Neoplasms, Male, Mesothelioma, Mesothelioma, Malignant, Multicenter Studies as Topic, Pleural Neoplasms, Quality of Life, Randomized Controlled Trials as Topic, Thoracic Surgery, Video-Assisted

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Future Oncol

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Informa UK Limited