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Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions.

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cam.issuedOnline2021-10
dc.contributor.authorDudas, Gytis
dc.contributor.authorHong, Samuel L
dc.contributor.authorPotter, Barney I
dc.contributor.authorCalvignac-Spencer, Sébastien
dc.contributor.authorNiatou-Singa, Frédéric S
dc.contributor.authorTombolomako, Thais B
dc.contributor.authorFuh-Neba, Terence
dc.contributor.authorVickos, Ulrich
dc.contributor.authorUlrich, Markus
dc.contributor.authorLeendertz, Fabian H
dc.contributor.authorKhan, Kamran
dc.contributor.authorHuber, Carmen
dc.contributor.authorWatts, Alexander
dc.contributor.authorOlendraitė, Ingrida
dc.contributor.authorSnijder, Joost
dc.contributor.authorWijnant, Kim N
dc.contributor.authorBonvin, Alexandre MJJ
dc.contributor.authorMartres, Pascale
dc.contributor.authorBehillil, Sylvie
dc.contributor.authorAyouba, Ahidjo
dc.contributor.authorMaidadi, Martin Foudi
dc.contributor.authorDjomsi, Dowbiss Meta
dc.contributor.authorGodwe, Celestin
dc.contributor.authorButel, Christelle
dc.contributor.authorŠimaitis, Aistis
dc.contributor.authorGabrielaitė, Miglė
dc.contributor.authorKatėnaitė, Monika
dc.contributor.authorNorvilas, Rimvydas
dc.contributor.authorRaugaitė, Ligita
dc.contributor.authorKoyaweda, Giscard Wilfried
dc.contributor.authorKandou, Jephté Kaleb
dc.contributor.authorJonikas, Rimvydas
dc.contributor.authorNasvytienė, Inga
dc.contributor.authorŽemeckienė, Živilė
dc.contributor.authorGečys, Dovydas
dc.contributor.authorTamušauskaitė, Kamilė
dc.contributor.authorNorkienė, Milda
dc.contributor.authorVasiliūnaitė, Emilija
dc.contributor.authorŽiogienė, Danguolė
dc.contributor.authorTiminskas, Albertas
dc.contributor.authorŠukys, Marius
dc.contributor.authorŠarauskas, Mantas
dc.contributor.authorAlzbutas, Gediminas
dc.contributor.authorAziza, Adrienne Amuri
dc.contributor.authorLusamaki, Eddy Kinganda
dc.contributor.authorCigolo, Jean-Claude Makangara
dc.contributor.authorMawete, Francisca Muyembe
dc.contributor.authorLofiko, Emmanuel Lokilo
dc.contributor.authorKingebeni, Placide Mbala
dc.contributor.authorTamfum, Jean-Jacques Muyembe
dc.contributor.authorBelizaire, Marie Roseline Darnycka
dc.contributor.authorEssomba, René Ghislain
dc.contributor.authorAssoumou, Marie Claire Okomo
dc.contributor.authorMboringong, Akenji Blaise
dc.contributor.authorDieng, Alle Baba
dc.contributor.authorJuozapaitė, Dovilė
dc.contributor.authorHosch, Salome
dc.contributor.authorObama, Justino
dc.contributor.authorAyekaba, Mitoha Ondo'o
dc.contributor.authorNaumovas, Daniel
dc.contributor.authorPautienius, Arnoldas
dc.contributor.authorRafaï, Clotaire Donatien
dc.contributor.authorVitkauskienė, Astra
dc.contributor.authorUgenskienė, Rasa
dc.contributor.authorGedvilaitė, Alma
dc.contributor.authorČereškevičius, Darius
dc.contributor.authorLesauskaitė, Vaiva
dc.contributor.authorŽemaitis, Lukas
dc.contributor.authorGriškevičius, Laimonas
dc.contributor.authorBaele, Guy
dc.contributor.orcidDudas, Gytis [0000-0002-0227-4158]
dc.contributor.orcidHong, Samuel L [0000-0001-6354-4943]
dc.contributor.orcidCalvignac-Spencer, Sébastien [0000-0003-4834-0509]
dc.contributor.orcidLeendertz, Fabian H [0000-0002-2169-7375]
dc.contributor.orcidHuber, Carmen [0000-0002-3744-4663]
dc.contributor.orcidBonvin, Alexandre MJJ [0000-0001-7369-1322]
dc.contributor.orcidMaidadi, Martin Foudi [0000-0002-6679-1111]
dc.contributor.orcidGabrielaitė, Miglė [0000-0002-7959-8767]
dc.contributor.orcidTamušauskaitė, Kamilė [0000-0003-1649-3439]
dc.contributor.orcidNorkienė, Milda [0000-0003-1679-2404]
dc.contributor.orcidVasiliūnaitė, Emilija [0000-0003-4084-1544]
dc.contributor.orcidŠukys, Marius [0000-0002-2432-0223]
dc.contributor.orcidAziza, Adrienne Amuri [0000-0002-5516-0779]
dc.contributor.orcidCigolo, Jean-Claude Makangara [0000-0002-1791-2247]
dc.contributor.orcidJuozapaitė, Dovilė [0000-0001-7240-4301]
dc.contributor.orcidHosch, Salome [0000-0001-9290-3589]
dc.contributor.orcidNaumovas, Daniel [0000-0002-5968-4182]
dc.contributor.orcidGedvilaitė, Alma [0000-0003-4779-0559]
dc.contributor.orcidBaele, Guy [0000-0002-1915-7732]
dc.date.accessioned2021-11-03T01:40:13Z
dc.date.available2021-11-03T01:40:13Z
dc.date.issued2021-10-01
dc.date.updated2021-11-03T01:40:12Z
dc.description.abstractDistinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SARS-CoV-2 lineage - designated B.1.620 - discovered in Lithuania and carrying many mutations and deletions in the spike protein shared with widespread variants of concern (VOCs), including E484K, S477N and deletions HV69Δ, Y144Δ, and LLA241/243Δ. As well as documenting the suite of mutations this lineage carries, we also describe its potential to be resistant to neutralising antibodies, accompanying travel histories for a subset of European cases, evidence of local B.1.620 transmission in Europe with a focus on Lithuania, and significance of its prevalence in Central Africa owing to recent genome sequencing efforts there. We make a case for its likely Central African origin using advanced phylogeographic inference methodologies incorporating recorded travel histories of infected travellers.
dc.identifier.doi10.17863/CAM.77655
dc.identifier.eissn2041-1723
dc.identifier.issn2041-1723
dc.identifier.otherPMC8486757
dc.identifier.other34599175
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330213
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1038/s41467-021-26055-8
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2041-1723
dc.sourcenlmid: 101528555
dc.subjectAfrica, Central
dc.subjectAntibodies, Neutralizing
dc.subjectCOVID-19
dc.subjectEurope
dc.subjectHumans
dc.subjectImmune Evasion
dc.subjectMutation
dc.subjectPhylogeny
dc.subjectPhylogeography
dc.subjectSARS-CoV-2
dc.subjectSpike Glycoprotein, Coronavirus
dc.subjectTravel
dc.titleEmergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions.
dc.typeArticle
dcterms.dateAccepted2021-09-15
prism.issueIdentifier1
prism.publicationNameNat Commun
prism.volume12
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41467-021-26055-8

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