Repository logo
 

Biopolymer‐based Carriers for DNA Vaccine Design

Published version
Peer-reviewed

Change log

Authors

Franck, Christoph O 
Fanslau, Luise 
Bistrovic Popov, Andrea 
Tyagi, Puneet 

Abstract

jats:titleAbstract</jats:title>jats:pOver the last 30 years, genetically engineered DNA has been tested as novel vaccination strategy against various diseases, including human immunodeficiency virus (HIV), hepatitis B, several parasites, and cancers. However, the clinical breakthrough of the technique is confined by the low transfection efficacy and immunogenicity of the employed vaccines. Therefore, carrier materials were designed to prevent the rapid degradation and systemic clearance of DNA in the body. In this context, biopolymers are a particularly promising DNA vaccine carrier platform due to their beneficial biochemical and physical characteristics, including biocompatibility, stability, and low toxicity. This article reviews the applications, fabrication, and modification of biopolymers as carrier medium for genetic vaccines.</jats:p>

Description

Keywords

32 Biomedical and Clinical Sciences, 3204 Immunology, Orphan Drug, Vaccine Related, Genetics, Rare Diseases, Bioengineering, Prevention, Infectious Diseases, Immunization, Biotechnology, Women's Health, 3.4 Vaccines, Infection, 3 Good Health and Well Being

Journal Title

Angewandte Chemie

Conference Name

Journal ISSN

0044-8249
1521-3757

Volume Title

133

Publisher

Wiley
Sponsorship
Engineering and Physical Sciences Research Council (EP/L015889/1)
Engineering and Physical Sciences Research Council (EP/S009000/1)