Biopolymer‐based Carriers for DNA Vaccine Design
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Abstract
jats:titleAbstract</jats:title>jats:pOver the last 30 years, genetically engineered DNA has been tested as novel vaccination strategy against various diseases, including human immunodeficiency virus (HIV), hepatitis B, several parasites, and cancers. However, the clinical breakthrough of the technique is confined by the low transfection efficacy and immunogenicity of the employed vaccines. Therefore, carrier materials were designed to prevent the rapid degradation and systemic clearance of DNA in the body. In this context, biopolymers are a particularly promising DNA vaccine carrier platform due to their beneficial biochemical and physical characteristics, including biocompatibility, stability, and low toxicity. This article reviews the applications, fabrication, and modification of biopolymers as carrier medium for genetic vaccines.</jats:p>
Description
Keywords
Journal Title
Conference Name
Journal ISSN
1521-3757
Volume Title
Publisher
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/S009000/1)