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Cortical tau is associated with microstructural imaging biomarkers of neurite density and dendritic complexity in Alzheimer's disease

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dc.contributor.authorWeston, Philip S. J.
dc.contributor.authorCoath, William
dc.contributor.authorHarris, Matthew J.
dc.contributor.authorMalone, Ian B.
dc.contributor.authorDickson, John
dc.contributor.authorAigbirhio, Franklin I.
dc.contributor.authorCash, David M.
dc.contributor.authorZhang, Hui
dc.contributor.authorSchott, Jonathan M.
dc.date.accessioned2023-03-18T16:01:19Z
dc.date.available2023-03-18T16:01:19Z
dc.date.issued2023-03-18
dc.date.submitted2022-11-14
dc.date.updated2023-03-18T16:01:18Z
dc.description.abstractIntroduction: In Alzheimer's disease (AD), hyperphosphorylated tau is closely associated with focal neurodegeneration, but the mechanism remains uncertain. Methods: We quantified cortical microstructure using neurite orientation dispersion and density imaging in 14 individuals with young onset AD. Diffusion tensor imaging measured mean diffusivity (MD). Amyloid beta and tau positron emission tomography were acquired and associations with microstructural measures were assessed. Results: When regional volume was adjusted for, in the medial temporal lobe there was a significant negative association between neurite density and tau (partial R2 = 0.56, p = 0.008) and between orientation dispersion and tau (partial R2 = 0.66, p = 0.002), but not between MD and tau. In a wider cortical composite, there was an association between orientation dispersion and tau (partial R2 = 0.43, p = 0.030), but not between other measures and tau. Discussion: Our findings are consistent with tau causing first dendritic pruning (reducing dispersion/complexity) followed by neuronal loss. Advanced magnetic resonance imaging (MRI) microstructural measures have the potential to provide information relating to underlying tau deposition.
dc.identifier.doi10.17863/CAM.95140
dc.identifier.issn1552-5260
dc.identifier.issn1552-5279
dc.identifier.otheralz13011
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/347724
dc.languageen
dc.subjectSHORT REPORT
dc.subjectAlzheimer's disease
dc.subjectcerebral cortex
dc.subjectdiffusion MRI
dc.subjectmicrostructure
dc.subjectneurite orientation dispersion and density imaging
dc.subjectpositron emission tomography
dc.subjecttau
dc.titleCortical tau is associated with microstructural imaging biomarkers of neurite density and dendritic complexity in Alzheimer's disease
dc.typeArticle
dcterms.dateAccepted2023-01-24
prism.publicationNameAlzheimer's & Dementia
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1002/alz.13011

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