Activity-induced instabilities of brain organoids.
We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids.
Funder: http://dx.doi.org/10.13039/501100007601; Grant(s): 722497
Villum Fonden (29476)
Horizon 2020 (847523)
Danmarks Frie Forskningsfond (DFF-117155-1001)
Engineering and Physical Sciences Research Council (EP/T031247/1)