Developing a novel risk prediction model for severe malarial anemia.
| cam.issuedOnline | 2017-09-11 | |
| cam.orpheus.success | Thu Jan 30 12:59:41 GMT 2020 - The item has an open VoR version. | |
| dc.contributor.author | Brickley, EB | |
| dc.contributor.author | Kabyemela, E | |
| dc.contributor.author | Kurtis, JD | |
| dc.contributor.author | Fried, M | |
| dc.contributor.author | Wood, AM | |
| dc.contributor.author | Duffy, PE | |
| dc.contributor.orcid | Brickley, EB [0000-0003-0280-2288] | |
| dc.date.accessioned | 2018-03-12T15:09:09Z | |
| dc.date.available | 2018-03-12T15:09:09Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | As a pilot study to investigate whether personalized medicine approaches could have value for the reduction of malaria-related mortality in young children, we evaluated questionnaire and biomarker data collected from the Mother Offspring Malaria Study Project birth cohort (Muheza, Tanzania, 2002-2006) at the time of delivery as potential prognostic markers for pediatric severe malarial anemia. Severe malarial anemia, defined here as a Plasmodium falciparum infection accompanied by hemoglobin levels below 50 g/L, is a key manifestation of life-threatening malaria in high transmission regions. For this study sample, a prediction model incorporating cord blood levels of interleukin-1β provided the strongest discrimination of severe malarial anemia risk with a C-index of 0.77 (95% CI 0.70-0.84), whereas a pragmatic model based on sex, gravidity, transmission season at delivery, and bed net possession yielded a more modest C-index of 0.63 (95% CI 0.54-0.71). Although additional studies, ideally incorporating larger sample sizes and higher event per predictor ratios, are needed to externally validate these prediction models, the findings provide proof of concept that risk score-based screening programs could be developed to avert severe malaria cases in early childhood. | |
| dc.format.medium | Electronic-eCollection | |
| dc.identifier.doi | 10.17863/CAM.20998 | |
| dc.identifier.eissn | 2054-4200 | |
| dc.identifier.issn | 2054-4200 | |
| dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/273921 | |
| dc.language | eng | |
| dc.language.iso | eng | |
| dc.publisher | Hindawi Limited | |
| dc.publisher.url | http://dx.doi.org/10.1017/gheg.2017.8 | |
| dc.rights | Attribution 4.0 International | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Anemia | |
| dc.subject | biomarkers | |
| dc.subject | cytokines | |
| dc.subject | malaria | |
| dc.subject | personalized medicine | |
| dc.subject | risk prediction | |
| dc.title | Developing a novel risk prediction model for severe malarial anemia. | |
| dc.type | Article | |
| dcterms.dateAccepted | 2017-05-15 | |
| prism.publicationDate | 2017 | |
| prism.publicationName | Glob Health Epidemiol Genom | |
| prism.startingPage | e14 | |
| prism.volume | 2 | |
| pubs.funder-project-id | Medical Research Council (G0701619) | |
| rioxxterms.licenseref.startdate | 2017-01 | |
| rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
| rioxxterms.type | Journal Article/Review | |
| rioxxterms.version | VoR | |
| rioxxterms.versionofrecord | 10.1017/gheg.2017.8 |
Files
Original bundle
1 - 2 of 2
Loading...
- Name:
- developing_a_novel_risk_prediction_model_for_severe_malarial_anemia.pdf
- Size:
- 701.52 KB
- Format:
- Adobe Portable Document Format
- Description:
- Published version
- Licence
- http://creativecommons.org/licenses/by/4.0/
No Thumbnail Available
- Name:
- Risk Prediction_revisedMS.docx
- Size:
- 237.25 KB
- Format:
- Microsoft Word XML
- Description:
- Accepted version
- Licence
- http://creativecommons.org/licenses/by/4.0/
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- DepositLicenceAgreement.pdf
- Size:
- 417.78 KB
- Format:
- Adobe Portable Document Format