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Tutorial on methods for estimation of optical absorption and scattering properties of tissue.

Accepted version
Peer-reviewed

Type

Article

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Abstract

SIGNIFICANCE: The estimation of tissue optical properties using diffuse optics has found a range of applications in disease detection, therapy monitoring, and general health care. Biomarkers derived from the estimated optical absorption and scattering coefficients can reflect the underlying progression of many biological processes in tissues. AIM: Complex light-tissue interactions make it challenging to disentangle the absorption and scattering coefficients, so dedicated measurement systems are required. We aim to help readers understand the measurement principles and practical considerations needed when choosing between different estimation methods based on diffuse optics. APPROACH: The estimation methods can be categorized as: steady state, time domain, time frequency domain (FD), spatial domain, and spatial FD. The experimental measurements are coupled with models of light-tissue interactions, which enable inverse solutions for the absorption and scattering coefficients from the measured tissue reflectance and/or transmittance. RESULTS: The estimation of tissue optical properties has been applied to characterize a variety of ex vivo and in vivo tissues, as well as tissue-mimicking phantoms. Choosing a specific estimation method for a certain application has to trade-off its advantages and limitations. CONCLUSION: Optical absorption and scattering property estimation is an increasingly important and accessible approach for medical diagnosis and health monitoring.

Description

Keywords

diffuse optics, optics, photonics, tissue optical properties, tissue optics, Scattering, Radiation, Phantoms, Imaging, Humans, Light, Optical Imaging, Animals, Absorption, Radiation, Algorithms

Journal Title

J Biomed Opt

Conference Name

Journal ISSN

1083-3668
1560-2281

Volume Title

Publisher

SPIE-Intl Soc Optical Eng
Sponsorship
Cancer Research UK (C14303/A17197)
Cancer Research UK (C14303/A17197)
Engineering and Physical Sciences Research Council (EP/R003599/1)
EPSRC (EP/X037770/1)
Herchel Smith Studentship Trust (RT), Deutsche Forschungsgemeinschaft (DFG German Research Foundation) under project GR 5824/1 (JG), Against Breast Cancer (LH), EPSRC (EP/R003599/1) (SEB)