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Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer.


Type

Article

Change log

Authors

Shi, J 
Zhang, Y 
Zheng, W 
Michailidou, K 

Abstract

Previous genome-wide association studies among women of European ancestry identified two independent breast cancer susceptibility loci represented by single nucleotide polymorphisms (SNPs) rs13281615 and rs11780156 at 8q24. A fine-mapping study across 2.06 Mb (chr8:127,561,724-129,624,067, hg19) in 55,540 breast cancer cases and 51,168 controls within the Breast Cancer Association Consortium was conducted. Three additional independent association signals in women of European ancestry, represented by rs35961416 (OR = 0.95, 95% CI = 0.93-0.97, conditional p = 5.8 × 10(-6) ), rs7815245 (OR = 0.94, 95% CI = 0.91-0.96, conditional p = 1.1 × 10(-6) ) and rs2033101 (OR = 1.05, 95% CI = 1.02-1.07, conditional p = 1.1 × 10(-4) ) were found. Integrative analysis using functional genomic data from the Roadmap Epigenomics, the Encyclopedia of DNA Elements project, the Cancer Genome Atlas and other public resources implied that SNPs rs7815245 in Signal 3, and rs1121948 in Signal 5 (in linkage disequilibrium with rs11780156, r(2)  = 0.77), were putatively functional variants for two of the five independent association signals. The results highlighted multiple 8q24 variants associated with breast cancer susceptibility in women of European ancestry.

Description

Keywords

8q24, breast cancer, fine-mapping, genetic susceptibility, single nucleotide polymorphism

Journal Title

International Journal of Cancer

Conference Name

Journal ISSN

0020-7136
1097-0215

Volume Title

139

Publisher

Wiley-Blackwell
Sponsorship
National Cancer Institute (R01CA128978)
National Cancer Institute (U19CA148537)
National Cancer Institute (U19CA148065)
Cancer Research Uk (None)
Cancer Research Uk (None)
European Commission (223175)
Cancer Research UK (10710)
Cancer Research UK (12014)
Cancer Research UK (10118)
Cancer Research Uk (None)
Cancer Research UK (16565)
CRUK, NIH, fp7 Numerous funders. Details can be found within the financial support section of the manuscript.