Could targeting the macrophage urokinase-type plasminogen activator receptor be a bullseye for PET imaging of atherosclerotic plaque inflammation?
| cam.depositDate | 2022-05-18 | |
| cam.issuedOnline | 2022-05-18 | |
| cam.orpheus.success | 2022-05-19 - Embargo set during processing via Fast-track | |
| dc.contributor.author | Tarkin, Jason M | |
| dc.contributor.author | Gonçalves, Isabel | |
| dc.contributor.orcid | Tarkin, Jason [0000-0002-9132-120X] | |
| dc.date.accessioned | 2022-05-19T23:30:23Z | |
| dc.date.available | 2022-05-19T23:30:23Z | |
| dc.date.issued | 2022-07 | |
| dc.date.updated | 2022-05-18T18:20:16Z | |
| dc.description.abstract | A myriad of imaging techniques and targets have been tested to identify high-risk plaques and ultimately improve patient cardiovascular risk-stratification [1]. In this issue of Atherosclerosis, Khare et al. examine the urokinase-type plasminogen activator receptor (uPAR) as a novel positron emission tomography (PET) imaging target in atherosclerosis [2]. The findings of this initial proof-of-concept study are intriguing: could targeting uPAR be a bullseye for PET imaging of atherosclerotic plaque inflammation? | |
| dc.identifier.doi | 10.17863/CAM.84736 | |
| dc.identifier.eissn | 1879-1484 | |
| dc.identifier.issn | 0021-9150 | |
| dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/337322 | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier BV | |
| dc.publisher.department | Department of Medicine | |
| dc.publisher.url | http://dx.doi.org/10.1016/j.atherosclerosis.2022.05.009 | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Atherosclerosis | |
| dc.subject | Inflammation | |
| dc.subject | Positron emission tomography | |
| dc.subject | Urokinase-type plasminogen activator receptor | |
| dc.subject | Humans | |
| dc.subject | Inflammation | |
| dc.subject | Macrophages | |
| dc.subject | Plaque, Atherosclerotic | |
| dc.subject | Positron-Emission Tomography | |
| dc.subject | Receptors, Urokinase Plasminogen Activator | |
| dc.subject | Urokinase-Type Plasminogen Activator | |
| dc.title | Could targeting the macrophage urokinase-type plasminogen activator receptor be a bullseye for PET imaging of atherosclerotic plaque inflammation? | |
| dc.type | Article | |
| dcterms.dateAccepted | 2022-05-12 | |
| prism.publicationDate | 2022 | |
| prism.publicationName | Atherosclerosis | |
| pubs.funder-project-id | Wellcome Trust (211100/Z/18/Z) | |
| pubs.licence-display-name | Apollo Repository Deposit Licence Agreement | |
| pubs.licence-identifier | apollo-deposit-licence-2-1 | |
| rioxxterms.type | Journal Article/Review | |
| rioxxterms.version | AM | |
| rioxxterms.versionofrecord | 10.1016/j.atherosclerosis.2022.05.009 |
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