Nutrition in early life and age-associated diseases.


Type
Article
Change log
Authors
Tarry-Adkins, Jane L 
Ozanne, Susan E 
Abstract

The prevalence of age-associated disease is increasing at a striking rate globally. It is known that a strong association exists between a suboptimal maternal and/or early-life environment and increased propensity of developing age-associated disease, including cardiovascular disease (CVD), type-2 diabetes (T2D) and obesity. The dissection of underlying molecular mechanisms to explain this phenomenon, which is known as 'developmental programming' is still emerging; however three common mechanisms have emerged in many models of developmental programming. These mechanisms are (a) changes in tissue structure, (b) epigenetic regulation and (c) accelerated cellular ageing. This review will examine the epidemiological evidence and the animal models of suboptimal maternal environments, focusing upon these molecular mechanisms and will discuss the progress being made in the development of safe and effective intervention strategies which ultimately could target those 'programmed' individuals who are known to be at-risk of age-associated disease.

Description
Keywords
Age-associated disease, Developmental programming, Mechanism, Oxidative stress, Sub-optimal nutrition, Aging, Animals, Cardiovascular Diseases, Cellular Senescence, Chronic Disease, Diabetes Mellitus, Type 2, Epigenesis, Genetic, Female, Humans, Models, Animal, Nutritional Status, Obesity, Pregnancy, Prenatal Exposure Delayed Effects
Journal Title
Ageing Res Rev
Conference Name
Journal ISSN
1568-1637
1872-9649
Volume Title
Publisher
Elsevier BV
Sponsorship
Medical Research Council (MC_UU_12012/4)
British Heart Foundation (None)
British Heart Foundation (None)
British Heart Foundation [Grant IDs: PG/09/037/27387, FS/09/029/27902]; Medical Research Council [Grant ID: MC UU 12012/4]