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Retromer and Its Role in Regulating Signaling at Endosomes.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Seaman, Matthew NJ 

Abstract

The retromer complex is a key element of the endosomal protein sorting machinery being involved in trafficking of proteins from endosomes to the Golgi and also endosomes to the cell surface. There is now accumulating evidence that retromer also has a prominent role in regulating the activity of many diverse signaling proteins that traffic through endosomes and this activity has profound implications for the functioning of many different cell and tissue types from neuronal cells to cells of the immune system to specialized polarized epithelial cells of the retina. In this review, the protein composition of the retromer complex will be described along with many of the accessory factors that facilitate retromer-mediated endosomal protein sorting to detail how retromer activity contributes to the regulation of several distinct signaling pathways.

Description

Keywords

Endosomal Sorting Complexes Required for Transport, Endosomes, Epithelial Cells, Golgi Apparatus, Humans, Immune System, Neurons, Retina, Signal Transduction, Vesicular Transport Proteins

Journal Title

Prog Mol Subcell Biol

Conference Name

Journal ISSN

0079-6484
2197-8484

Volume Title

57

Publisher

Springer International Publishing
Sponsorship
Medical Research Council (MR/L007533/1)