Retromer and Its Role in Regulating Signaling at Endosomes.


Type
Article
Change log
Authors
Seaman, Matthew NJ 
Abstract

The retromer complex is a key element of the endosomal protein sorting machinery being involved in trafficking of proteins from endosomes to the Golgi and also endosomes to the cell surface. There is now accumulating evidence that retromer also has a prominent role in regulating the activity of many diverse signaling proteins that traffic through endosomes and this activity has profound implications for the functioning of many different cell and tissue types from neuronal cells to cells of the immune system to specialized polarized epithelial cells of the retina. In this review, the protein composition of the retromer complex will be described along with many of the accessory factors that facilitate retromer-mediated endosomal protein sorting to detail how retromer activity contributes to the regulation of several distinct signaling pathways.

Description
Keywords
Endosomal Sorting Complexes Required for Transport, Endosomes, Epithelial Cells, Golgi Apparatus, Humans, Immune System, Neurons, Retina, Signal Transduction, Vesicular Transport Proteins
Journal Title
Prog Mol Subcell Biol
Conference Name
Journal ISSN
0079-6484
2197-8484
Volume Title
57
Publisher
Springer International Publishing
Sponsorship
Medical Research Council (MR/L007533/1)