Current Management of Intracranial Germ Cell Tumours.


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Type
Article
Change log
Authors
Bowzyk Al-Naeeb, A 
Horan, G 
Harris, F 
Kortmann, R-D 
Abstract

Intracranial germ cell tumours (icGCTs) are uncommon tumours occurring in children and young adults. They are usually segregated into germinomas and non-germinomatous tumours (NGGCTs) in most classifications. Germinomas are highly curable tumours with multimodality treatment, but NGGCTs are associated with poorer survival outcomes. There are some differences in the approach to the management of icGCTs globally. Current research generally focuses on reducing treatment intensity, particularly the dose and volume of radiotherapy, in order to minimise the risks of late sequelae while maintaining high cure rates in icGCTs.

Description
Keywords
Chemotherapy, germinoma, intracranial germ cell tumours, non-germinoma, radiotherapy, Adolescent, Brain Neoplasms, Child, Combined Modality Therapy, Disease Progression, Female, Humans, Male, Neoplasms, Germ Cell and Embryonal, Young Adult
Journal Title
Clin Oncol (R Coll Radiol)
Conference Name
Journal ISSN
0936-6555
1433-2981
Volume Title
30
Publisher
Elsevier BV