Biomembrane-based organic electronic devices for ligand-receptor binding studies.


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Article
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Authors
Liu, Han-Yuan 
Pappa, Anna-Maria 
Hidalgo, Tania Cecilia 
Inal, Sahika 
Owens, Rόisín M 
Abstract

We present a simple, rapid method for forming supported lipid bilayers on organic electronic devices composed of conducting polymer electrodes using a solvent-assisted lipid bilayer formation method. These supported bilayers present protein recognition elements that are mobile, critical for multivalent binding interactions. Because these polymers are transparent and conducting, we demonstrate, by optical and electrical detection, the specific interactions of proteins with these biomembrane-based bioelectronic devices. This work paves the way for easy formation of biomembrane mimetics for sensing and detection of binding events in a label-free manner on organic electronic devices of more sophisticated architectures. Graphical abstract.

Description
Keywords
Bioelectronic, Biosensor, PEDOT:PSS, Protein recognition, Supported lipid bilayer, Animals, Biomimetics, Biosensing Techniques, Biotinylation, Cattle, Electric Conductivity, Electrodes, Electronics, Equipment Design, Ligands, Lipid Bilayers, Polystyrenes, Protein Binding, Proteins, Serum Albumin, Bovine, Thiophenes
Journal Title
Anal Bioanal Chem
Conference Name
Journal ISSN
1618-2642
1618-2650
Volume Title
412
Publisher
Springer Science and Business Media LLC