A Practical Method for Continuous Production of sp3-Rich Compounds from (Hetero)Aryl Halides and Redox-Active Esters.


Type
Article
Change log
Authors
Watanabe, Eiichi 
May, Oliver 
Abstract

A practically useful coupling reaction between aromatic halides and redox-active esters was realized by nickel catalysis through the use of a packed zinc bed column in continuous flow. Multiple reuse of the column showed a negligible decrease in efficiency, affording high space/time yields. A wide range of substrates, including a number of heteroaryl halides and polyfunctional materials were coupled in generally good yields. Longer-time and larger-scale experiments further demonstrates the robustness of the system.

Description
Keywords
continuous flow, cross-coupling, nickel, packed-column, redox-active ester
Journal Title
Chemistry
Conference Name
Journal ISSN
0947-6539
1521-3765
Volume Title
26
Publisher
Wiley
Rights
All rights reserved
Sponsorship
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (737266)