Lineage selection and plasticity in the intestinal crypt.


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Authors
Winton, Douglas J 
Abstract

We know more about the repertoire of cellular behaviours that define the stem and progenitor cells maintaining the intestinal epithelium than any other renewing tissue. Highly dynamic and stochastic processes define cell renewal. Historically the commitment step in differentiation is viewed as a ratchet, irreversibly promoting a given fate and corresponding to a programme imposed at the point of cell division. However, the emerging view of intestinal self-renewal is one of plasticity in which a stem cell state is easily reacquired. The pathway mediators of lineage selection are largely known but how they interface within highly dynamic populations to promote different lineages and yet permit plasticity is not. Advances in understanding gene regulation in the nervous system suggest possible mechanisms.

Description
Keywords
Animals, Cell Differentiation, Cell Division, Humans, Intestinal Mucosa, Signal Transduction, Stem Cells
Journal Title
Curr Opin Cell Biol
Conference Name
Journal ISSN
0955-0674
1879-0410
Volume Title
31
Publisher
Elsevier BV
Sponsorship
Medical Research Council (MR/K018329/1)
Cancer Research UK (C14303/A17197)
AP was supported by Medical Research Council Research grant MR/K018329/1. DJW is funded by Cancer Research UK.