Using genetic designs to identify likely causal environmental contributions to psychopathology.


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Type
Article
Change log
Authors
Sellers, Ruth 
Riglin, Lucy 
Harold, Gordon T 
Abstract

The multifactorial nature of psychopathology, whereby both genetic and environmental factors contribute risk, has long been established. In this paper, we provide an update on genetically informative designs that are utilized to disentangle genetic and environmental contributions to psychopathology. We provide a brief reminder of quantitative behavioral genetic research designs that have been used to identify potentially causal environmental processes, accounting for genetic contributions. We also provide an overview of recent molecular genetic approaches that utilize genome-wide association study data which are increasingly being applied to questions relevant to psychopathology research. While genetically informative designs typically have been applied to investigate the origins of psychopathology, we highlight how these approaches can also be used to elucidate potential causal environmental processes that contribute to developmental course and outcomes. We highlight the need to use genetically sensitive designs that align with intervention and prevention science efforts, by considering strengths-based environments to investigate how positive environments can mitigate risk and promote children's strengths.

Description
Keywords
environment, genetics, psychopathology, strength-based approaches
Journal Title
Dev Psychopathol
Conference Name
Journal ISSN
0954-5794
1469-2198
Volume Title
34
Publisher
Cambridge University Press (CUP)
Sponsorship
Economic and Social Research Council (ES/N003098/1)
Economic and Social Research Council (ES/L014718/1)