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Using genetic designs to identify likely causal environmental contributions to psychopathology.

Accepted version
Peer-reviewed

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Type

Article

Change log

Authors

Sellers, Ruth 
Riglin, Lucy 
Harold, Gordon T 

Abstract

The multifactorial nature of psychopathology, whereby both genetic and environmental factors contribute risk, has long been established. In this paper, we provide an update on genetically informative designs that are utilized to disentangle genetic and environmental contributions to psychopathology. We provide a brief reminder of quantitative behavioral genetic research designs that have been used to identify potentially causal environmental processes, accounting for genetic contributions. We also provide an overview of recent molecular genetic approaches that utilize genome-wide association study data which are increasingly being applied to questions relevant to psychopathology research. While genetically informative designs typically have been applied to investigate the origins of psychopathology, we highlight how these approaches can also be used to elucidate potential causal environmental processes that contribute to developmental course and outcomes. We highlight the need to use genetically sensitive designs that align with intervention and prevention science efforts, by considering strengths-based environments to investigate how positive environments can mitigate risk and promote children's strengths.

Description

Keywords

environment, genetics, psychopathology, strength-based approaches

Journal Title

Dev Psychopathol

Conference Name

Journal ISSN

0954-5794
1469-2198

Volume Title

34

Publisher

Cambridge University Press (CUP)
Sponsorship
Economic and Social Research Council (ES/N003098/1)
Economic and Social Research Council (ES/L014718/1)