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Investigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length

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dc.contributor.authorDempsey, Paddy C.
dc.contributor.authorMusicha, Crispin
dc.contributor.authorRowlands, Alex V.
dc.contributor.authorDavies, Melanie
dc.contributor.authorKhunti, Kamlesh
dc.contributor.authorRazieh, Cameron
dc.contributor.authorTimmins, Iain
dc.contributor.authorZaccardi, Francesco
dc.contributor.authorCodd, Veryan
dc.contributor.authorNelson, Christopher P.
dc.contributor.authorYates, Tom
dc.contributor.authorSamani, Nilesh J.
dc.contributor.orcidDempsey, Paddy C. [0000-0002-1714-6087]
dc.contributor.orcidRazieh, Cameron [0000-0003-3597-2945]
dc.contributor.orcidTimmins, Iain [0000-0002-8761-582X]
dc.date.accessioned2022-05-19T15:00:36Z
dc.date.available2022-05-19T15:00:36Z
dc.date.issued2022-04-20
dc.date.submitted2021-09-17
dc.date.updated2022-05-19T15:00:36Z
dc.description.abstractAbstract: Walking pace is a simple and functional form of movement and a strong predictor of health status, but the nature of its association with leucocyte telomere length (LTL) is unclear. Here we investigate whether walking pace is associated with LTL, which is causally associated with several chronic diseases and has been proposed as a marker of biological age. Analyses were conducted in 405,981 UK Biobank participants. We show that steady/average and brisk walkers had significantly longer LTL compared with slow walkers, with accelerometer-assessed measures of physical activity further supporting this through an association between LTL and habitual activity intensity, but not with total amount of activity. Bi-directional mendelian randomisation analyses suggest a causal link between walking pace and LTL, but not the other way around. A faster walking pace may be causally associated with longer LTL, which could help explain some of the beneficial effects of brisk walking on health status. Given its simple measurement and low heritability, self-reported walking pace may be a pragmatic target for interventions.
dc.identifier.doi10.17863/CAM.84724
dc.identifier.eissn2399-3642
dc.identifier.others42003-022-03323-x
dc.identifier.other3323
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337311
dc.languageen
dc.publisherNature Publishing Group UK
dc.subjectArticle
dc.subject/692/308/53/2423
dc.subject/692/499
dc.subject/692/53
dc.subjectarticle
dc.titleInvestigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length
dc.typeArticle
dcterms.dateAccepted2022-03-25
prism.issueIdentifier1
prism.publicationNameCommunications Biology
prism.volume5
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s42003-022-03323-x

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