Manganese( ii ) promotes prebiotically plausible non-enzymatic RNA ligation reactions †
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Peer-reviewed
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Authors
Liu, Ziwei https://orcid.org/0000-0002-1812-2538
Jiang, Clancy Zhijian
Bond, Andrew D. https://orcid.org/0000-0002-1744-0489
Tosca, Nicholas J.
Sutherland, John D.
Abstract
Using different prebiotically plausible activating reagents, the RNA ligation yield was significantly increased in the presence of Mn(ii). The mechanism of the activation reaction has been investigated using 5′-AMP as an analogue.
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The Royal Society of Chemistry
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Sponsorship
Simons Foundation (290362)
Leverhulme Trust (RC-2021-032)
Medical Research Council (MC_UP_A024_1009)
Leverhulme Trust (RC-2021-032)
Medical Research Council (MC_UP_A024_1009)