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Manganese( ii ) promotes prebiotically plausible non-enzymatic RNA ligation reactions †

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Peer-reviewed

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Authors

Jiang, Clancy Zhijian 
Tosca, Nicholas J. 
Sutherland, John D. 

Abstract

Using different prebiotically plausible activating reagents, the RNA ligation yield was significantly increased in the presence of Mn(ii). The mechanism of the activation reaction has been investigated using 5′-AMP as an analogue.

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Publisher

The Royal Society of Chemistry
Sponsorship
Simons Foundation (290362)
Leverhulme Trust (RC-2021-032)
Medical Research Council (MC_UP_A024_1009)