DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Hänsel-Hertsch, Robert
Di Antonio, Marco https://orcid.org/0000-0002-7321-1867
Balasubramanian, Shankar https://orcid.org/0000-0002-0281-5815
Abstract
Single-stranded guanine-rich DNA sequences can fold into four-stranded DNA structures called G-quadruplexes (G4s) that arise from the self-stacking of two or more guanine quartets. There has been considerable recent progress in the detection and mapping of G4 structures in the human genome and in biologically relevant contexts. These advancements, many of which align with predictions made previously in computational studies, provide important new insights into the functions of G4 structures in, for example, the regulation of transcription and genome stability, and uncover their potential relevance for cancer therapy.
Description
Keywords
Animals, DNA Replication, DNA, Single-Stranded, G-Quadruplexes, Gene Expression Regulation, Genome, Human, Genomic Instability, Humans, Neoplasms, Oligonucleotides, Transcription, Genetic
Journal Title
Nat Rev Mol Cell Biol
Conference Name
Journal ISSN
1471-0072
1471-0080
1471-0080
Volume Title
18
Publisher
Springer Science and Business Media LLC
Publisher DOI
Sponsorship
Wellcome Trust (099232/Z/12/Z)
Cancer Research UK (18618)
Cancer Research UK (19836)
Cancer Research UK (18618)
Cancer Research UK (19836)
The Balasubramanian laboratory is core-funded by Cancer Research UK (C14303/A17197) and further supported by a Cancer Research UK programme grant (C9681/A18618). S.B. is a Wellcome Trust Senior Investigator (099232/Z/12/Z).