Repository logo
 

DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Hänsel-Hertsch, Robert 
Balasubramanian, Shankar  ORCID logo  https://orcid.org/0000-0002-0281-5815

Abstract

Single-stranded guanine-rich DNA sequences can fold into four-stranded DNA structures called G-quadruplexes (G4s) that arise from the self-stacking of two or more guanine quartets. There has been considerable recent progress in the detection and mapping of G4 structures in the human genome and in biologically relevant contexts. These advancements, many of which align with predictions made previously in computational studies, provide important new insights into the functions of G4 structures in, for example, the regulation of transcription and genome stability, and uncover their potential relevance for cancer therapy.

Description

Keywords

Animals, DNA Replication, DNA, Single-Stranded, G-Quadruplexes, Gene Expression Regulation, Genome, Human, Genomic Instability, Humans, Neoplasms, Oligonucleotides, Transcription, Genetic

Journal Title

Nat Rev Mol Cell Biol

Conference Name

Journal ISSN

1471-0072
1471-0080

Volume Title

18

Publisher

Springer Science and Business Media LLC
Sponsorship
Wellcome Trust (099232/Z/12/Z)
Cancer Research UK (18618)
Cancer Research UK (19836)
The Balasubramanian laboratory is core-funded by Cancer Research UK (C14303/A17197) and further supported by a Cancer Research UK programme grant (C9681/A18618). S.B. is a Wellcome Trust Senior Investigator (099232/Z/12/Z).