Mechanical Characterization of Human Brain Tissue and SoftDynamic Gels Exhibiting Electromechanical Neuro-Mimicry

Change log
Mommer, Stefan 
Tabet, Anthony 
Vigil, Julian 
Hallou, Clement 

Synthetic hydrogels are an important class of materialsin tissue engineering, drug delivery, and other biomedicalfields. Their mechanical and electrical properties can betuned to match those of biological tissues. In this work,we report on hydrogels that exhibit both mechanical andelectrical biomimicry. The presented dual networks consistof supramolecular networks formed from 2:1 homoternarycomplexes of imidazolium-based guest molecules in cucu-bit[8]uril and covalent networks of oligoethylene glycol-(di)methacrylate. We also investigate the viscoelastic prop-erties of human brain tissues. The mechanical properties ofthe dual network gels are benchmarked against the humantissue, and we find that they both are neuro-mimetic and ex-hibit cytocompatiblity in a neural stem cell model.

Journal Title
Advanced Healthcare Materials
Conference Name
Journal ISSN
Volume Title
Royal Society (NF170062)
Academy of Medical Sciences (unknown)
The Winston Churchill Foundation of the United States. The Newton International Fellowship.