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Microcalcification crystallography as a potential marker of DCIS recurrence.

Published version
Peer-reviewed

Repository DOI


Type

Article

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Abstract

Ductal carcinoma in-situ (DCIS) accounts for 20-25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatment. To identify unique prognostic biomarkers of invasive progression, crystallographic and chemical features of DCIS microcalcifications have been explored. Samples from patients with at least 5-years of follow up and no known recurrence (174 calcifications in 67 patients) or ipsilateral invasive breast cancer recurrence (179 microcalcifications in 57 patients) were studied. Significant differences were noted between the two groups including whitlockite relative mass, hydroxyapatite and whitlockite crystal maturity and, elementally, sodium to calcium ion ratio. A preliminary predictive model for DCIS to invasive cancer progression was developed from these parameters with an AUC of 0.797. These results provide insights into the differing DCIS tissue microenvironments, and how these impact microcalcification formation.

Description

Keywords

Humans, Female, Carcinoma, Intraductal, Noninfiltrating, Carcinoma, Ductal, Breast, Crystallography, Calcinosis, Breast Neoplasms, Neoplasm Recurrence, Local, Tumor Microenvironment

Journal Title

Sci Rep

Conference Name

Journal ISSN

2045-2322
2045-2322

Volume Title

13

Publisher

Springer Science and Business Media LLC