Significance of Cellular Lipid Metabolism for the Replication of Rotaviruses and Other RNA Viruses.
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Abstract
The replication of species A rotaviruses (RVAs) involves the recruitment of and interaction with cellular organelles' lipid droplets (LDs), both physically and functionally. The inhibition of enzymes involved in the cellular fatty acid biosynthesis pathway or the inhibition of cellular lipases that degrade LDs was found to reduce the functions of 'viral factories' (viroplasms for rotaviruses or replication compartments of other RNA viruses) and decrease the production of infectious progeny viruses. While many other RNA viruses utilize cellular lipids for their replication, their detailed analysis is far beyond this review; only a few annotations are made relating to hepatitis C virus (HCV), enteroviruses, SARS-CoV-2, and HIV-1.
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Peer reviewed: True
Acknowledgements: For rotavirus research, the author gratefully acknowledges the collaboration with Oscar Burrone, Winsome Cheung, Serge Chwetzoff, Nathalie Couroussé, Sue E Crawford, Alessandro Esposito, Eleanor Gaunt, Michael Gill, Clemens F Kaminski, Nandita Keshavan, Andrew M L Lever, James E Richards, Germain Trugnan, the late Michael JO Wakelam, and Qifeng Zhang.
Publication status: Published
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1999-4915
